Nuclear transplantation: reprogramming of transplanted nuclei
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چکیده
منابع مشابه
Nuclear transplantation: reprogramming of transplanted nuclei.
Recent results in animal cloning have demonstrated that the events of cell differentiation can be reversed. This reversal necessarily requires genetic reprogramming of the transplanted nucleus. It has emerged from review articles that synthesis of nuclear and ribosomal RNA is blocked after fusion independently of cell cycle stage of the transferred nucleus, and that the cytoplasm condition of t...
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A fundamental question in cell and developmental biology concerns how nuclei progressively acquire differentiated functions. Although the nucleus of a fertilized egg is totipotent in that all of the differentiated cell types found in the adult organism can be derived from it, this is not the case for the vast majority of somatic nuclei in the adult animal. This limitation of the genomic potenti...
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Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
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There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
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ژورنال
عنوان ژورنال: Reproduction Nutrition Development
سال: 1999
ISSN: 0926-5287
DOI: 10.1051/rnd:19990503